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	Provedor de dados Biological Sciences (1) Autor Dhayabaran, Violet (1) Margret, Arockiya Anita (1) Parthasarathy, Subbiah (1) Suvaithenamudhan, Suvaiarasan (1) Palavra-chave Animal despair studies (1) Ayurvedic herb (1) Kaempferol 3-O-(2״ 6״-di-O-rhamnopyranosyl) glucopyranoside (1) Mental health (1) Molecular docking. (1) Rhodamine transport assay (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2019 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Analysing the antidepressant and drug efflux competence of Clitoria ternatea L. as P-glycoprotein inhibitor to facilitate blood brain barrier Biological Sciences Margret, Arockiya Anita; Dhayabaran, Violet; Suvaithenamudhan, Suvaiarasan; Parthasarathy, Subbiah. Clitoria ternatea L. is a vital ayurvedic herb featured with a wide spectrum of mental health benefits. The present study investigates the competence of the plant against depression and to inhibit the membrane efflux protein P-glycoprotein (P-gp) that can regulate and restrict drug permeation into the brain. Antidepressant competence of the aqueous plant extract was assessed by animal despair studies on depression induced female mice models. The P-glycoprotein inhibitory potential of active phytocompounds was evaluated by molecular docking assay and substantiated by a cell line study. The in vivo studies exhibited a significant difference in the immobility time thereby establishing antidepressant activity. The histopathological sections from cortex region... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mental health; Ayurvedic herb; Kaempferol 3-O-(2״ 6״-di-O-rhamnopyranosyl) glucopyranoside; Animal despair studies; Rhodamine transport assay; Molecular docking.. Ano: 2019 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/46629 Registros recuperados: 1 Primeira ... 1 ... Última

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